PECULIARITIES OF MORPHOGENESIS OF CHANGES IN THE PERIODONTIUM AT EXPERIMENTAL ACTION OF OPIOID DURING TWO WEEKS AND ITS SUBSEQUENT FOUR WEEKS CANCELLATION AND CORRECTION

Fik V B Fik V B,Halyuk U M Halyuk U M,Mota O M Mota O M,Palʹtov Ye V PalʹTov Ye V

doi:10.31435/rsglobal_sr/30062020/7136

Abstract

The aim of the study was to examine the periodontal tissues of white rats under two weeks of opioid exposure, after its abolition and drug correction for four weeks at the optical level. After two weeks of experimental action of the opioid analgesic and its subsequent four-week withdrawal, pronounced irreversible changes in the structural components of the periodontium of animals were not detected, however, and their complete recovery was not observed. The proposed drug correction with pentoxifylline and ceftriaxone with opioid withdrawal after two weeks of its administration, led to the restoration of microcirculation and trophic tissues of periodontal tissues of rats, their morphological organization was approaching normal.

Highlights

IntroductionThe data about condition of the oral cavity organs and tissues during drug withdrawal are extremely important [11, 12], since the analysis of changes in soft tissues of parodontium at drug addiction should contribute to the development of adequate treatment measures [2, 7]
The results of the article correspond to the research plan of Lviv National Medical University named after Danylo Halytsky and are part of the research topic of the Department of Normal Anatomy "Morpho-functional features of organs in the pre- and postnatal periods of ontogenesis, under the influence of opioids, food additives, reconstructive surgery and obesity", state registration number 0120U002129
In the professional literature we have not found data about the features of structural changes in parodontium affected by opioid analgesic and correction of these changes through its abolition or using of medicines

Summary

Introduction

The data about condition of the oral cavity organs and tissues during drug withdrawal are extremely important [11, 12], since the analysis of changes in soft tissues of parodontium at drug addiction should contribute to the development of adequate treatment measures [2, 7]. In this aspect, the pathogenetically substantiated medicine pentoxifylline, which is used in case of microcirculation disorders, has antioxidant and anti-inflammatory effects [9]. The aim was to investigate the biopsy specimens of rats’ parodontal tissues at a two-weeks period of opioid exposure, after its cancellation and medicamental correction during four weeks at the light-optic level

Objectives

Methods

Conclusion