Abstract
Recent studies reported that higher triiodothyronine(T3)/thyroxine(T4) ratio was associated with a higher prevalence of metabolic syndrome (MetS) in euthyroid population. However, the association between T3/T4 ratio and MetS conditions in patients who received thyroidectomy is unknown. A cross-sectional study was conducted using electronic medical records. Patients who received thyroidectomy (partial/full) at a Medical Center between 2014 and 2016 were identified. Incidences of MetS conditions (dyslipidemia, hypertension, diabetes or obesity) were identified using diagnoses, medications, and problem list. Patients with documented prior MetS conditions were excluded. Patient characteristics collected in the six months before or on the surgery date were compared across quartiles of T3/T4 ratio and those significant at p<0.2 were used in a logistic regression to assess the association between T3/T4 ratios and the MetS conditions. Among 528 patients who received partial/full thyroidectomy, 73 had same-day T3 and T4 measures within one year post surgery. After excluding patients with prior MetS conditions, 37 were retained and 20 of them had at least one of the MetS conditions. After adjusting for covariates, there was no statistically significant association between T3/T4 and incidences of hypertension (OR=0.48, p=0.278) or dyslipidemia (OR=0.83, p=0.798) after surgery. Older age was associated with a higher risk of hypertension (OR=1.05, p=0.049) and receiving full thyroidectomy trended towards a lower risk of hypertension (OR=0.1, p=0.085). T3/T4 was not associated with MetS conditions after thyroidectomy. However, due to infrequent testing of T3 and T4, our sample is very small and large studies are needed to confirm the findings.
Published Version
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