PDB1 Type 1 Diabetes Is Associated with Urinary System and Genital TRACT Disorders in Women

Abstract

Type 1 diabetes can lead to different complications including macro- and microvascular disorders, and osteoporosis. However, only limited data on the association between type 1 diabetes (T1D) and urinary system and genital tract disorders was published. The aim of this work was to estimate this association among women with T1D treated in gynecological practices in Germany. This retrospective cross-sectional study included women aged 16 years or older with T1D diagnosis between January 2015 and December 2018 from 268 gynecological practices in Germany (IMS Disease Analyzer database). T1D patients were 1:5 matched with patients without diabetes by age, and physician. The main outcome of the study was the prevalence of different urinary system, breast, pelvic organ and genital tract disorders documented between the first T1D diagnosis documentation between and the last outpatient visit. Multivariate logistic regression models were fitted with all study disorders as dependent variables, and T1D as impact variable. In each model, the effect of T1d on the defined disorder was adjusted for all other study disorders. The present study included 1,357 women with and 1,357 women without T1D (mean age 45.6 years). T1D was significantly associated with acute vulvitis (OR: 2.12 (95% CI: 1.56-2.90), other specified urinary incontinence (OR: 1.64 (95% CI: 1.19-2.26), acute cystitis (OR: 1.46 (95% CI: 1.10-1.95), and absent, scanty and rare menstruation (OR: 1.37 (95% CI: 1.13-1.67). These findings may have implications for the future care of women with T1D. First, the focus should not only be on diabetes management but also on recognizing and treating additional comorbidities including urinary system and genital tract disorders. Further studies are required to investigate the association between T1D and increased risk of urinary system and genital tract disorders.