PD48-12 ARE NEUTROPHIL-LYMPHOCYTE AND PLATELET-LYMPHOCYTE RATIOS USEFUL FOR DETERMINING ACTIVE PHASE PEYRONIE'S DISEASE?

Abstract

You have accessJournal of UrologySexual Function/Dysfunction: Peyronie's Disease (PD48)1 Sep 2021PD48-12 ARE NEUTROPHIL-LYMPHOCYTE AND PLATELET-LYMPHOCYTE RATIOS USEFUL FOR DETERMINING ACTIVE PHASE PEYRONIE'S DISEASE? Jacob W. Greenberg, Joseph Kim, Joshua Pincus, Maxwell L. Sandberg, Brian P. Dick, Rachel M. Greenberg, Omer Raheem, and Wayne J.G. Hellstrom Jacob W. GreenbergJacob W. Greenberg More articles by this author , Joseph KimJoseph Kim More articles by this author , Joshua PincusJoshua Pincus More articles by this author , Maxwell L. SandbergMaxwell L. Sandberg More articles by this author , Brian P. DickBrian P. Dick More articles by this author , Rachel M. GreenbergRachel M. Greenberg More articles by this author , Omer RaheemOmer Raheem More articles by this author , and Wayne J.G. HellstromWayne J.G. Hellstrom More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002070.12AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Management options for Peyronie's disease (PD) are determined by the phase of the patient’s condition. Experts counsel against surgical intervention during active phase PD. Chronic phase PD patients are offered either collagenase clostridium histolyticum injections or surgical intervention. Accurately characterizing a patient’s phase of PD is crucial in determining the appropriate treatment option. This study sought to investigate if patient’s neutrophil-lymphocyte-ratio (NLR) and platelet-lymphocyte-ratio (PLR) could be used to determine acute or chronic phase of PD. METHODS: This study retrospectively queried all patients who presented for initial diagnosis of PD from 2016-2020 and had complete blood count (CBC) laboratory values before initial therapy. Active phase PD was defined as a changing penile curvature or growing palpable plaque, commonly witnessed within the first 12 months after initial onset. Chronic phase PD was defined as a stabilized penile curvature with or without a palpable plaque, usually ≥1 year after initial diagnosis. All statistical analyses were two-tailed, using a significance level of 0.05. RESULTS: 109 patients were entered into this study cohort: 27 active phase patients (25%) and 82 (75%) chronic phase. Demographic and erectile characteristics were not statistically different between the two groups. The active phase cohort demonstrated a shorter duration of PD when compared to the chronic phase, 9.0 and 32 months, respectively (p <0.0001). NLR and PLR values between active and chronic phase patients were comparable (p >0.05). A linear regression evaluated correlations between the duration of PD and either NLR or PLR. Neither NLR or PLR was correlated with PD duration, p=0.31 and p=0.89, respectively. A multivariable logistic regression was performed when analyzing predictors for phase of PD. NLR and PLR were not noted to be predictors of PD phase, p=0.22 and p=0.74, respectively. Lastly, a receiver operator characteristic curve was generated. NLR and PLR yielded an area under curve of 58% and 57.8%, respectively. CONCLUSIONS: Two recent studies suggested NLR and PLR could be used to predict the phase of PD. However, after evaluating a cohort of 109 men from our institution our data does not support the use of PLR or NLR to determine the phase of PD. Source of Funding: N/a © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e842-e843 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Jacob W. Greenberg More articles by this author Joseph Kim More articles by this author Joshua Pincus More articles by this author Maxwell L. Sandberg More articles by this author Brian P. Dick More articles by this author Rachel M. Greenberg More articles by this author Omer Raheem More articles by this author Wayne J.G. Hellstrom More articles by this author Expand All Advertisement Loading ...