PD44-10 CORRELATION BETWEEN DIAMETER OF PROSTATE CANCER FOCI ON MULTIPARAMETRIC PROSTATE MRI AND WHOLE MOUNT HISTOPATHOLOGY: STRATIFIED BY PI-RADS AND GLEASON SCORE

Abstract

You have accessJournal of UrologyProstate Cancer: Detection and Screening IV1 Apr 2015PD44-10 CORRELATION BETWEEN DIAMETER OF PROSTATE CANCER FOCI ON MULTIPARAMETRIC PROSTATE MRI AND WHOLE MOUNT HISTOPATHOLOGY: STRATIFIED BY PI-RADS AND GLEASON SCORE Pooria Khoshnoodi, Nelly Tan, Daniel J.A. Margolis, Wei-Chan Lin, Somrach Thamtorawat, David Y. Lu, Jiaoti Huang, Robert E. Reiter, and Steven S. Raman Pooria KhoshnoodiPooria Khoshnoodi More articles by this author , Nelly TanNelly Tan More articles by this author , Daniel J.A. MargolisDaniel J.A. Margolis More articles by this author , Wei-Chan LinWei-Chan Lin More articles by this author , Somrach ThamtorawatSomrach Thamtorawat More articles by this author , David Y. LuDavid Y. Lu More articles by this author , Jiaoti HuangJiaoti Huang More articles by this author , Robert E. ReiterRobert E. Reiter More articles by this author , and Steven S. RamanSteven S. Raman More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.2556AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Multiparametric magnetic resonance imaging (MP-MRI) has become increasingly popular to evaluate prostate cancer (CaP). Our objective was to correlate diameter of tumor region of interest (ROI) on prostate MP-MRI with diameter of concordant foci at whole mount histopathology (WMHP) stratified by PI-RADS and Gleason Score(GS). METHODS A HIPPA-compliant, IRB approved study of 254 consecutive men who underwent prostate MP-MRI before radical prostatectomy (RP) was performed. MP-MRI and WMHP features were obtained. The index tumor was defined as the lesion with the highest GS or largest tumor if multiple foci had the identical GS. A genitourinary radiologist and pathologist reviewed each case to match each MRI ROI to the concordant foci on WMHP. Maximal diameter of corresponding tumor measured on WMHP and MRI. Correlation scatter plots were drawn and Pearson correlation coefficient rho(ρ) was calculated to determine strength of correlation between size of tumors stratified by GS and PI-RADS. A p-value of 0.05 was considered significant. RESULTS The 254 patients had 279 CaP foci on WMHP matched with MP-MRI ROIs concordantly. The 201 tumors out of 279 were index tumors. Of 279 CaP foci, GS was 6(3+3) in 79 (28.31%), 7(3+4) in 117 (41.94%), 7(4+3) in 50 (17.92%) and ≥8 in 33 (11.83%). Of 279 CaP foci, overall PI-RADS of ROI at MR was 2 in 28 (10.04%), 3 in 113 (40.50%), 4 in 84 (30.11%) and 5 in (19.35%). The Pearson correlation coefficient (ρ) between the MR tumor diameter size and the WMHP size was 0.45 and 0.49 for total tumors and index tumors respectively (p<0.05). The rho between the tumor diameter on MR and WMHP are 0.42, 0.67 and 0.61 for tumors with GS=3+4, GS=4+3 and GS≥8 respectively (p<0.05). Rho was 0.28, 0.52 and 0.73 for tumors with overall PI-RADS of 3, 4 and 5 respectively (p<0.05). CONCLUSIONS Size of index and non-index tumors on MP-MRI correlates with WMHP. This correlation becomes stronger for lesions with higher PI-RADS or Gleason Scores. However, true size is consistently underestimated. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e900-e901 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Pooria Khoshnoodi More articles by this author Nelly Tan More articles by this author Daniel J.A. Margolis More articles by this author Wei-Chan Lin More articles by this author Somrach Thamtorawat More articles by this author David Y. Lu More articles by this author Jiaoti Huang More articles by this author Robert E. Reiter More articles by this author Steven S. Raman More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...