MP21-16 3T MULTI-PARAMETRIC MRI PERFORMANCE IN PROSTATE CANCER DETECTION: PERIPHERAL ZONE TUMORS VS. TRANSITIONAL ZONE

Abstract

You have accessJournal of UrologyProstate Cancer: Detection & Screening III1 Apr 2016MP21-16 3T MULTI-PARAMETRIC MRI PERFORMANCE IN PROSTATE CANCER DETECTION: PERIPHERAL ZONE TUMORS VS. TRANSITIONAL ZONE Nazanin Asvadi, Pooria Khoshnoodi, Hector Alcala, Amin Moshksar, Daniel Margolis, Anthony Sisk, Jiaoti Huang, Robert Reiter, and Steven Raman Nazanin AsvadiNazanin Asvadi More articles by this author , Pooria KhoshnoodiPooria Khoshnoodi More articles by this author , Hector AlcalaHector Alcala More articles by this author , Amin MoshksarAmin Moshksar More articles by this author , Daniel MargolisDaniel Margolis More articles by this author , Anthony SiskAnthony Sisk More articles by this author , Jiaoti HuangJiaoti Huang More articles by this author , Robert ReiterRobert Reiter More articles by this author , and Steven RamanSteven Raman More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.650AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES To evaluate the prostate cancer (CaP) detection rate by 3T multi-parametric MR imaging (mp-MRI) confirmed by whole mount histopathology (WMHP) for peripheral zone (PZ) and transitional zone (TZ) lesions stratified by Gleason Scores (GS) and Prostate Imaging-Reporting and Data Systems (PI-RADS). METHODS A HIPPA-compliant, IRB-approved study of 339 consecutive men who underwent prostate MP-MRI before radical prostatectomy (RP) from October 2010 to September 2015 was performed. Clinical, MP-MRI (T2W, DWI and DCE) and pathologic features (WMHP slides, GS, maximal diameter) were obtained. The index tumor was defined as the pathological lesion with the highest GS or largest tumor when multiple foci had identical GS. A genitourinary (GU) radiologist and a GU pathologist reviewed each case and matched all lesions on WMHP with true positive tumors concordant for size and location on MRI and WMHP. Detection of tumors by GS, location, PI-RADS score and tumor size (<1 cm defined as small vs. ≥ 1cm as large tumor) was reported. Chi-squared tests were used to test difference in MRI tumor detection rates by location and PI-RADS score. Analyses were conducted using Stata 14.0. P-values below .05 were considered significant. RESULTS 339 patients had 464 region of interest (ROI) on mp-MRI. Of 464 total ROIs on mp-MRI, 323 (69.6%) were located in PZ and 131 (28.2%) were in TZ. Median tumor diameters of PZ and TZ lesions were 1.2 cm and 1.3 cm, respectively. On mp-MRI, 80.5% (260/323) ROIs in PZ and 67.1% (88/131) in TZ were true positives (p<.05) and 92.5% of ROIs with high PI-RADS scores (4 & 5) detected in PZ compared to 83% of ROIs in TZ (p<.05). There was no significant difference between distribution of low grade small ROIs and high grade small ROIs in TZ and PZ (p<.05) and also no significant difference between distribution of low grade large ROIs and high grade large ROIs (p<.05). CONCLUSIONS There was a significantly higher rate of matched tumor detection on 3T mp-MRI in PZ than TZ and also significantly higher tumor detection rate for highly suspicious PI-RADS (4 and 5) lesions in PZ compared to TZ confirmed with WMHP. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e251 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Nazanin Asvadi More articles by this author Pooria Khoshnoodi More articles by this author Hector Alcala More articles by this author Amin Moshksar More articles by this author Daniel Margolis More articles by this author Anthony Sisk More articles by this author Jiaoti Huang More articles by this author Robert Reiter More articles by this author Steven Raman More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...