PD42-11 68GA-PSMA PET/CT PROVIDES ACCURATE STAGING OF LYMPH NODE REGIONS PRIOR TO LYMPH NODE DISSECTION IN PATIENTS WITH PROSTATE CANCER

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You have accessJournal of UrologyProstate Cancer: Staging I1 Apr 2016PD42-11 68GA-PSMA PET/CT PROVIDES ACCURATE STAGING OF LYMPH NODE REGIONS PRIOR TO LYMPH NODE DISSECTION IN PATIENTS WITH PROSTATE CANCER Annika Herlemann, Vera Wenter, Alexander Kretschmer, Peter Bartenstein, Christian G. Stief, Christian Gratzke, and Wolfgang P. Fendler Annika HerlemannAnnika Herlemann More articles by this author , Vera WenterVera Wenter More articles by this author , Alexander KretschmerAlexander Kretschmer More articles by this author , Peter BartensteinPeter Bartenstein More articles by this author , Christian G. StiefChristian G. Stief More articles by this author , Christian GratzkeChristian Gratzke More articles by this author , and Wolfgang P. FendlerWolfgang P. Fendler More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.1763AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES 68Ga-PSMA-HBED-CC (68Ga-PSMA) PET/CT has received considerable attention as new diagnostic tool for prostate cancer (PCa) staging. We evaluated the accuracy of 68Ga-PSMA PET/CT for nodal staging prior to lymph node dissection (LND) in patients with PCa. METHODS 34 patients with histologically proven PCa underwent 68Ga-PSMA PET/CT prior to radical prostatectomy with primary lymph node dissection (pLND; n=20) and PET/CT prior to secondary lymph node dissection (sLND; n=14). Accuracy (ACC) of PET and CT were analyzed separately for staging of the following 71 lymph node (LN) regions: pelvic left (n=30), pelvic right (n=31), presacral (n=3), and paraaortic (n=7). Postoperative histopathology was taken as reference standard. RESULTS Overall 484 LNs were resected from 71 regions. 132 nodes from 37 regions (52%) showed LN metastases on histopathology. Sensitivity, specificity, positive predictive value, negative predictive value for detection of LN metastases were 84, 82, 84, 82% for PET and 65, 76, 75, 67% for CT. PET was more accurate for nodal staging as compared to CT in both, pLND (88 versus 75%) and sLND (77 versus 65%). On a patient basis PET demonstrated a SE of 91%, PPV of 83%, NPV of 80% for detection of LN metastases. SP was lower (67%); the overall ACC for detection of N stage was 82% on a patient basis. CONCLUSIONS Our study demonstrates high accuracy of 68Ga-PSMA PET/CT for nodal staging in PCa patients both before primary and secondary LND. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e992 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Annika Herlemann More articles by this author Vera Wenter More articles by this author Alexander Kretschmer More articles by this author Peter Bartenstein More articles by this author Christian G. Stief More articles by this author Christian Gratzke More articles by this author Wolfgang P. Fendler More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...