PD35-02 RISK STRATIFICATION MODEL, INCLUDING HEMATOLOGICAL PARAMETERS, IN PATIENTS WITH UPPER URINARY TRACT UROTHELIAL CARCINOMA UNDERGOING RADICAL NEPHROURETERECTOMY

Abstract

You have accessJournal of UrologyBladder Cancer: Upper Tract Tumors I1 Apr 2014PD35-02 RISK STRATIFICATION MODEL, INCLUDING HEMATOLOGICAL PARAMETERS, IN PATIENTS WITH UPPER URINARY TRACT UROTHELIAL CARCINOMA UNDERGOING RADICAL NEPHROURETERECTOMY Shuichi Morizane, Hideto Iwamoto, Toshihiko Masago, Akihisa Yao, Masashi Honda, Takehiro Sejima, and Atsushi Takenaka Shuichi MorizaneShuichi Morizane More articles by this author , Hideto IwamotoHideto Iwamoto More articles by this author , Toshihiko MasagoToshihiko Masago More articles by this author , Akihisa YaoAkihisa Yao More articles by this author , Masashi HondaMasashi Honda More articles by this author , Takehiro SejimaTakehiro Sejima More articles by this author , and Atsushi TakenakaAtsushi Takenaka More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.2415AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES While a few preoperative hematological parameters that can predict the recurrence and prognosis in patients with upper urinary tract urothelial carcinoma have been elucidated, the risk factors for prognosis are still a matter of debate. We investigate the prognostic indicators, including preoperative hematological factors, in patients undergoing radical nephroureterectomy for upper urinary tract urothelial carcinoma, and develop a prognostic factor-based risk stratification model. METHODS Data were collected from 345 consecutive upper urinary tract urothelial carcinoma patients treated with radical nephroureterectomy without neoadjuvant therapy. The prognostic value of preoperative hematological parameters and clinicopathological factors were evaluated. A risk stratification model was developed to predict poor survival after radical nephroureterectomy using the regression coefficients of multivariate analysis. RESULTS In multivariate analysis, high preoperative serum creatinine levels (¡Ý 1.0 mg/dl), high preoperative serum C-reactive protein levels (¡Ý 0.5 mg/dl), tumor grade (G3), lymph node metastasis, infiltration (¦Ã) and positive surgical margin were independent factors predicting poor recurrence-free survival. High preoperative serum creatinine level (¡Ý 1.0 mg/dl), tumor grade (G3), lymph node metastasis and a high number of tumor foci (> 1) were independent factors predicting poor cancer-specific survival. The risk stratification model revealed significant differences in recurrence-free survival and cancer-specific survival between the three subgroups. The 5-year recurrence-free survival/ cancer-specific survival in patients at low-, intermediate- and high-risk was 86.8%/ 91.5%, 78.9%/ 86.3% and 24.3%/ 20.5%, respectively. (Fig. 1) CONCLUSIONS This study indicates that not only clinicopathological factors, but also preoperative markers, such as serum creatinine and C-reactive protein levels, predict poor survival in patients with UUT-UC. Our risk stratification model may provide physicians with useful prognostic information for identifying patients who may be candidates for multimodal treatment. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e891 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Shuichi Morizane More articles by this author Hideto Iwamoto More articles by this author Toshihiko Masago More articles by this author Akihisa Yao More articles by this author Masashi Honda More articles by this author Takehiro Sejima More articles by this author Atsushi Takenaka More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...