PD29-06 MALE LIFESTYLE AND PATHOLOGICAL CONDITIONS ASSOCIATED WITH COUPLE INFERTILITY IN A REFERRAL CENTER IN ITALY: A CROSS-SECTIONAL STUDY OF 13452 MALE PATIENTS

Abstract

You have accessJournal of UrologyInfertility: Epidemiology & Evaluation II (PD29)1 Sep 2021PD29-06 MALE LIFESTYLE AND PATHOLOGICAL CONDITIONS ASSOCIATED WITH COUPLE INFERTILITY IN A REFERRAL CENTER IN ITALY: A CROSS-SECTIONAL STUDY OF 13452 MALE PATIENTS Serena Maruccia, Luca Boeri, Mario Mignini Renzini, Mariabeatrice Dal Canto, Josè Buratini, Lucia Maragno, Paolo Spiga, and Stefano Casellato Serena MarucciaSerena Maruccia More articles by this author , Luca BoeriLuca Boeri More articles by this author , Mario Mignini RenziniMario Mignini Renzini More articles by this author , Mariabeatrice Dal CantoMariabeatrice Dal Canto More articles by this author , Josè BuratiniJosè Buratini More articles by this author , Lucia MaragnoLucia Maragno More articles by this author , Paolo SpigaPaolo Spiga More articles by this author , and Stefano CasellatoStefano Casellato More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002030.06AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Current literature suggests an association between male infertility and a wide range of other comorbid conditions, ranging from oncologic, cardiovascular, autoimmune, and metabolic disorders. The exact nature of this association remains somewhat unclear, although hypothesized mechanisms include genetic, developmental, and lifestyle-based factors. The purpose of the present study is to survey the data of a group of 13452 male patients who referred to an infertility clinic in Italy and to investigate the relationship between couple infertility and overall male health METHODS: We analysed data from 13452 male patients seeking medical help for couple infertility at a single referral center between 01/2013 and 12/2019. Sociodemographic data, lifestyle and recreational habits were collected. The WHO 2010 referral criteria were used to categorized semen parameters as pathological or normal. Descriptive statistics was applied to describe the whole cohort RESULTS: The median age was 41.5 years (95% CI ±0,09). Above all, 8209 (61.0%) men had pathological semen parameters (any type), while 5243 (39.0%) individuals reported normal semen parameters. Among patients with pathological semen analysis, 3666 (44.6%) men had a sperm concentration <15mln/ml, 3689 (44.9%) had a total sperm count <39 mln, 4695 (57.1%) had a motility <32% and 6764 (82,3%) men had a normal morphology <4%. In terms of health comorbidities, patient’s with abnormal semen parameters more frequently reported a history of hypertension [941 (11.4%) vs. 234 (4.4%)], diabetes mellitus [804 (9.7%) vs. 178 (3.3%)] and cardiovascular diseases [613 (7.4%) vs. 160 (3.0%)], than those with normal semen analysis (all p<0.001). Testis cancer was more frequently found in men with abnormal semen parameters [140 (1.7%) vs. 24 (0,4%), p<0.001]. Men with impaired semen parameters were more frequently active smokers [3336 (40.6%) vs. 764 (14.5%)] and alcohol consumers [208 (2.5%) vs. 15 (0.2%)] than those with normal semen parameters (all p<0.001) while the use of substances of abuse was similar among groups. A history of allergic diseases was more frequently found in men with impaired semen analysis [2031 (24.7%) vs. 477 (9.0%); p<0.001]. Overall, 1091 IUI, 7443 ICSI and 1348 FIVET were performed CONCLUSIONS: Our study showed that oncologic, cardiovascular, metabolic and allergic diseases are more frequent in infertile men with impaired semen analysis than in those with normal semen parameters. Additional research is required to clarify the relationship between couple infertility and overall men’s health Source of Funding: none © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e528-e529 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Serena Maruccia More articles by this author Luca Boeri More articles by this author Mario Mignini Renzini More articles by this author Mariabeatrice Dal Canto More articles by this author Josè Buratini More articles by this author Lucia Maragno More articles by this author Paolo Spiga More articles by this author Stefano Casellato More articles by this author Expand All Advertisement Loading ...