LBA01-09 MALE LIFESTYLE AND PATHOLOGICAL CONDITIONS ASSOCIATED WITH COUPLE INFERTILITY IN A REFERRAL CENTER IN ITALY: A CROSS-SECTIONAL STUDY OF 13452 MALE PATIENTS.

Abstract

You have accessJournal of UrologyLate-Breaking Abstracts (LBA1)1 Apr 2020LBA01-09 MALE LIFESTYLE AND PATHOLOGICAL CONDITIONS ASSOCIATED WITH COUPLE INFERTILITY IN A REFERRAL CENTER IN ITALY: A CROSS-SECTIONAL STUDY OF 13452 MALE PATIENTS. Claudia Signorini, San Donato, Serena Maruccia*, Maria Beatrice Dal Canto, Josè Buratini, Cristina Guglielmo, Mario Mignini Renzini, Damiano Vizziello, Luca Carmignani, and Stefano Casellato Claudia SignoriniClaudia Signorini More articles by this author , San DonatoSan Donato More articles by this author , Serena Maruccia*Serena Maruccia* More articles by this author , Maria Beatrice Dal CantoMaria Beatrice Dal Canto More articles by this author , Josè BuratiniJosè Buratini More articles by this author , Cristina GuglielmoCristina Guglielmo More articles by this author , Mario Mignini RenziniMario Mignini Renzini More articles by this author , Damiano VizzielloDamiano Vizziello More articles by this author , Luca CarmignaniLuca Carmignani More articles by this author , and Stefano CasellatoStefano Casellato More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000946.09AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Introduction: Current literature suggests an association between male infertility and a wide range of other comorbid conditions, ranging from oncologic, cardiovascular, autoimmune, and metabolic disorders. The exact nature of this association remains somewhat unclear, although hypothesized mechanisms include genetic, developmental, and lifestyle-based factors. The purpose of the present study is to survey the data of a group of 13452 male patients who referred to an infertility clinic in Italy and to investigate the relationship between couple infertility and overall male health. Methods: We analysed data from 13452 male patients seeking medical help for couple infertility at a single referral center between 01/2013 and 12/2019. Sociodemographic data, lifestyle and recreational habits were collected. The WHO 2010 referral criteria were used to categorized semen parameters as pathological or normal. Descriptive statistics was applied to describe the whole cohort. Results: The median age was 41.5 years (95% CI ±0,09). Above all, 8209 (61.0%) men had pathological semen parameters (any type), while 5243 (39.0%) individuals reported normal semen parameters. Among patients with pathological semen analysis, 3666 (44.6%) men had a sperm concentration <15mln/ml, 3689 (44.9%) had a total sperm count <39 mln, 4695 (57.1%) had a motility <32% and 6764 (82,3%) men had a normal morphology <4%. In terms of comorbidities, patient’s with abnormal semen parameters more frequently reported a history of hypertension [941 (11.4%) vs. 234 (4.4%)], diabetes mellitus [804 (9.7%) vs. 178 (3.3%)] and cardiovascular diseases [613 (7.4%) vs. 160 (3.0%)], than those with normal semen analysis (all p<0.001). Testis cancer was more frequently found in men with abnormal semen parameters [140 (1.7%) vs. 24 (0,4%), p<0.001]. They were more frequently active smokers [3336 (40.6%) vs. 764 (14.5%)] and alcohol consumers [208 (2.5%) vs. 15 (0.2%)] than those with normal semen parameters (all p<0.001) while the use of substances of abuse was similar among groups. A history of allergic diseases was more frequently found in men with impaired semen analysis [2031 (24.7%) vs. 477 (9.0%); p<0.001]. Overall, 1091 IUI, 7443 ICSI and 1348 FIVET were performed. Conclusions: Our study showed that oncologic, cardiovascular, metabolic and allergic diseases are more frequent in infertile men with impaired semen analysis than in those with a normal exam. Additional research is required to clarify the relationship between couple infertility and overall men’s health. Source of Funding: none © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e1022-e1023 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Claudia Signorini More articles by this author San Donato More articles by this author Serena Maruccia* More articles by this author Maria Beatrice Dal Canto More articles by this author Josè Buratini More articles by this author Cristina Guglielmo More articles by this author Mario Mignini Renzini More articles by this author Damiano Vizziello More articles by this author Luca Carmignani More articles by this author Stefano Casellato More articles by this author Expand All Advertisement PDF downloadLoading ...