PD18-08 IMPACT OF COMORBIDITIES ON CHANGES IN SERUM TESTOSTERONE AMONG MEN FROM THE BALTIMORE LONGITUDINAL STUDY OF AGING

Abstract

You have accessJournal of UrologyCME1 Apr 2023PD18-08 IMPACT OF COMORBIDITIES ON CHANGES IN SERUM TESTOSTERONE AMONG MEN FROM THE BALTIMORE LONGITUDINAL STUDY OF AGING Aaron Gurayah, Chase Carto, Meghan Grewal, Maria Camila Suarez Arbelaez, Taylor Kohn, and Ranjith Ramasamy Aaron GurayahAaron Gurayah More articles by this author , Chase CartoChase Carto More articles by this author , Meghan GrewalMeghan Grewal More articles by this author , Maria Camila Suarez ArbelaezMaria Camila Suarez Arbelaez More articles by this author , Taylor KohnTaylor Kohn More articles by this author , and Ranjith RamasamyRanjith Ramasamy More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003273.08AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Previous studies have reported that testosterone (T) levels decrease with age in men. However, the role of acquired comorbidities in aging males has been mostly unaccounted for in prior studies investigating this relationship. Thus, we aimed to evaluate the association between age and T levels as well as the impact of having several comorbidities on this association. We hypothesized that age would not be associated with T levels, after accounting for number of patient comorbidities. METHODS: Participants were selected from the Baltimore Longitudinal Study of Aging. Data was obtained on presence of several comorbidities and total testosterone (TT) level during each visit. A univariable and stepwise multivariable panel regression was used to determine the impact of age on TT level while controlling for individual comorbidities. RESULTS: A total of 625 men were included in this study, with a median age of 70±15 years, average follow-up time of 6.7 years, and overall mean TT level of 463±180 ng/dL. In our univariable model, we found several predictors, including age, that were significantly associated with a decline in TT (Table 1). On our multivariable-adjusted model, age was not associated with a decline in TT, while anemia, diabetes mellitus, heart failure, obesity, peripheral artery disease, and stroke were inversely associated with TT levels (Table 1). We found that having 2-4 comorbidities or 5 or more comorbidities was associated with a decline in TT (65 ng/dL and 112 ng/dL, respectively), when compared to those without comorbidities (Table 2). CONCLUSIONS: We report that when adjusted for the presence of concomitant comorbidities, age alone does not predict a significant decline in T level over time. However, a decrease in T levels is likely due to the development of various comorbidities with increasing age. With the overall increase in life expectancy, and the simultaneous rise in the prevalence of comorbidities, our findings may help optimize screening and treatment for late-onset hypogonadism in patients with multiple comorbidities. Source of Funding: This work was supported by NIH Grant R01 DK 130991 and Clinician Scientist Development Grant from the ACS to RR © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e505 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Aaron Gurayah More articles by this author Chase Carto More articles by this author Meghan Grewal More articles by this author Maria Camila Suarez Arbelaez More articles by this author Taylor Kohn More articles by this author Ranjith Ramasamy More articles by this author Expand All Advertisement PDF downloadLoading ...