MP21-15 PREDICTORS OF LOW TOTAL TESTOSTERONE (TT) LEVELS AFTER RADICAL ORCHIECTOMY (RO) FOR TESTIS CANCER (TC)

Abstract

You have accessJournal of UrologyCME1 May 2022MP21-15 PREDICTORS OF LOW TOTAL TESTOSTERONE (TT) LEVELS AFTER RADICAL ORCHIECTOMY (RO) FOR TESTIS CANCER (TC) Jose M. Flores, Nicole Benfante, and John P. Mulhall Jose M. FloresJose M. Flores More articles by this author , Nicole BenfanteNicole Benfante More articles by this author , and John P. MulhallJohn P. Mulhall More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002554.15AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Clinical experience shows that many men experience low TT levels after RO for TC. The literature cites a prevalence of up to 20%. The aim of this study is to define prevalence and predictors of low TT in this population. METHODS: Patients who had (i) unilateral RO for TC (ii) had two, early morning TT levels post-RO (iii) which was measured using LCMS constituted the study population. Chemo/radiation therapy pre or post-RO T therapy were exclusions. Demographics, comorbidity and endocrine profile pre and post-RO were recorded. We describe the prevalence of low TT (<300 ng/dl) pre and post RO as well as changes in TT level after RO, including the proportion of men who dropped < 300 ng/dL and ≥ 100 ng/dL. We performed multivariable analysis to evaluate predictors of low TT as well of a significant drop (≥ 100 ng/dL) after RO. RESULTS: 152 men were analyzed. Mean age was 44±16 years. Mean TT level pre-RO was 403±253. 34% of these men had T levels ≤300 ng/dL. 5% had diabetes, 13% had OSA. Median time between RO and postoperative TT measurement was 2 (1-6) months. Mean TT level post-RO were 403±253 and 54±49 ng/dL. Representing a median -67 ng/dL drop in TT levels. Post-RO, 51% had low TT levels, 40% with normal TT levels pre-RO had low TT post-RO, and 41% dropped ≥100 ng/dL in TT. After multivariable assessment, only age at RO was predictive of low post-RO TT or dropping TT ≥ 100 ng/dL after RO (pre-RO age, per 10 years increase, OR 1.44, 95%CI 1.12-1.85, p value 0.005). CONCLUSIONS: In our cohort of men with TC and RO, approximately half of the men with TC had low TT levels and 40% dropped ≥ 100 ng/dL in TT levels post-surgery. Older age at the time of the RO increased the likelihood of low TT or a decrease of ≥ 100 ng/dL in TT levels post-RO. Source of Funding: None © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 207Issue Supplement 5May 2022Page: e333 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information Jose M. Flores More articles by this author Nicole Benfante More articles by this author John P. Mulhall More articles by this author Expand All Advertisement PDF DownloadLoading ...