PD02-10 THE HUMORAL IMMUNITY ACTIVATION CAUSES THE BLADDER OUTLET OBSTRUCTION RELATED WITH PROSTATE THROUGH THE DIFFERENT MECHANISM FROM THE PROSTATE VOLUME

Abstract

You have accessJournal of UrologyCME1 Apr 2023PD02-10 THE HUMORAL IMMUNITY ACTIVATION CAUSES THE BLADDER OUTLET OBSTRUCTION RELATED WITH PROSTATE THROUGH THE DIFFERENT MECHANISM FROM THE PROSTATE VOLUME Hidenori Akaihata, Yuki Harigane, Kei Yaginuma, Yu Endo, Yuki Yoshida, Hitomi Imai, Yuta Matsuoka, Akifumi Onagi, Kanako Matsuoka, Seiji Hoshi, Tomoyuki Koguchi, Junya Hata, Yuichi Sato, Masao Kataoka, Motohide Uemura, and Yoshiyuki Kojima Hidenori AkaihataHidenori Akaihata More articles by this author , Yuki HariganeYuki Harigane More articles by this author , Kei YaginumaKei Yaginuma More articles by this author , Yu EndoYu Endo More articles by this author , Yuki YoshidaYuki Yoshida More articles by this author , Hitomi ImaiHitomi Imai More articles by this author , Yuta MatsuokaYuta Matsuoka More articles by this author , Akifumi OnagiAkifumi Onagi More articles by this author , Kanako MatsuokaKanako Matsuoka More articles by this author , Seiji HoshiSeiji Hoshi More articles by this author , Tomoyuki KoguchiTomoyuki Koguchi More articles by this author , Junya HataJunya Hata More articles by this author , Yuichi SatoYuichi Sato More articles by this author , Masao KataokaMasao Kataoka More articles by this author , Motohide UemuraMotohide Uemura More articles by this author , and Yoshiyuki KojimaYoshiyuki Kojima More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003219.10AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The prostate volume and morphological features of the prostate are well known to be associated with bladder outlet obstruction (BOO) in the male patients. However, the causative agents and factors of BOO are multifactorial and incompletely understood. This study aims to find out the novel mechanism underlying bladder outlet obstruction (BOO) except for prostate volume and morphological features by comprehensive gene expression analysis (CGEA). METHODS: A total of 31 patients who had a diagnosis of benign by the random prostate biopsy were enrolled in this study. CGEA was performed with prostate specimens obtained by the biopsy. The patients were divided into control group (prostate volume <30 mL) and benign prostatic enlargement (BPE) group (prostate volume ≥30 mL). Hierarchical clustering was performed to identify the clusters with similar gene expression by the genes indicated significantly different between two groups by t-test. The uroflowmetry parameters were compared among each cluster. The protocol was approved by the ethics committee of Fukushima Medical University. RESULTS: CGEA selected 12 genes with significant difference in mean converted value between control and BPE (p<0.01) from 11,907 genes. Hierarchical clustering analysis using these 12 genes categorized three different clusters: the control (n=8), the BPE (n=11) and BPE with inflammatory (n=12) clusters. As compared BPE cluster, the BPE with inflammatory cluster have activation of humoral immunity (increased VSIG2 gene), more suppression of estrogen receptor signaling (reduced ELK4 gene) and more decreased angiogenesis (reduced MME gene). The maximum flow rate was significantly lower in the BPE with inflammatory cluster than in the control cluster (p=0.03). There was no significant difference about the maximum flow rate between control cluster and BPE cluster. CONCLUSIONS: Our results suggested that humoral immunity activation, estrogen receptor signaling suppression and decreased angiogenesis reduced maximal urinary flow rate in the patients with large prostate volume. The activation of humoral immunity in addition to the change of estrogen receptor signaling and angiogenesis causes BOO related with prostate through the different mechanism from the prostate volume. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e72 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Hidenori Akaihata More articles by this author Yuki Harigane More articles by this author Kei Yaginuma More articles by this author Yu Endo More articles by this author Yuki Yoshida More articles by this author Hitomi Imai More articles by this author Yuta Matsuoka More articles by this author Akifumi Onagi More articles by this author Kanako Matsuoka More articles by this author Seiji Hoshi More articles by this author Tomoyuki Koguchi More articles by this author Junya Hata More articles by this author Yuichi Sato More articles by this author Masao Kataoka More articles by this author Motohide Uemura More articles by this author Yoshiyuki Kojima More articles by this author Expand All Advertisement PDF downloadLoading ...