Abstract
Relevance. Prognostic value of PD-L1 expression in oral cavity squamous cell carcinoma (OCSCC) and its effect on survival is still controversial. It should be to determine the prognostic role of PD-L1 expression on tumor and immune cells of OCSCC and assess their effect on overall survival (OS) and progression-free survival (PFS).Materials and methods. A prospective study included 145 patients, first diagnosed with OCSCC. PD-L1 expression on tumor and immune cells, infiltrating tumor and its microenvironment, was assessed in all tumor samples by IHC, CPS was calculated. Cut-off values were determined by ROC analysis for identification of PD-L1 expression effect on OS and PFS.Results. Most patients with oral mucosa squamous cell carcinoma showed positive expression of PD-L1 on tumor (77.2%) and immune cells (92.4%). The median PD-L1 expression on tumor cells was 13.5% [1.0-40.0], the median PD-L1 expression on immune cells was 5.0% [1.0-11.0], and the median CPS – 18.0 [3.0-7.8]. Univariate and multivariate analyses revealed a significant negative effect of PD-L1 expression on immune cells ≤ 7% on OS (HR 0.66; 95% CI 0.45-0.93; p = 0.0498); PD-L1 expression in tumor cells ≤ 15% (HR 0.65; 95% CI 0.43-0.98; p = 0.0416) and CPS ≤ 21 (HR 0.62; 95% CI 0.44-0.92; p = 0.0183) for PFS. PD-L1 expression in tumor cells ≤ 6% (HR 0.71; 95% CI 0.47-1.08; p = 0.1096) and CPS ≤ 7 (RR 0.67; 95% CI 0.44-1.01; p = 0.0575) had a confident tendency to negative impact on OS.Conclusion. Positive PD-L1 expression in tumor and immune cells as well as CPS are effective additional factors in the prognosis of the disease course, OS and PFS in patients with OCSCC.
Highlights
Univariate and multivariate analyses revealed a significant negative effect of PD-L1 expression on immune cells ≤ 7% on overall survival (OS) (HR 0.66; 95% CI 0.45-0.93; p = 0.0498); PD-L1 expression in tumor cells ≤ 15% (HR 0.65; 95% CI 0.43-0.98; p = 0.0416) and Combined positive score (CPS) ≤ 21 (HR 0.62; 95% CI 0.44-0.92; p = 0.0183) for progression-free survival (PFS)
PD-L1 expression in tumor cells ≤ 6% (HR 0.71; 95% CI 0.47-1.08; p = 0.1096) and CPS ≤ 7 (RR 0.67; 95% CI 0.44-1.01; p = 0.0575) had a confident tendency to negative impact on OS
МАТЕРИАЛЫ И МЕТОДЫ ИССЛЕДОВАНИЯ Для достижения поставленной цели нами проведено проспективное исследование, объектом которого стали 145 больных с впервые верифицированным диагнозом «плоскоклеточный рак слизистой оболочки полости рта»
Summary
Основной целью нашего исследования было определение уровня экспрессии PD-L1 на опухолевых и иммунных клетках эпителиальных злокачественных опухолей слизистой оболочки полости рта, а также оценка влияния экспрессии PD-L1 на показатели общей выживаемости больных и выживаемости без прогрессирования. В ходе анализа было выявлено, что медиана экспрессии PD-L1 на опухолевых клетках плоскоклеточного рака слизистой оболочки полости рта составила 13,5% [1,0-40,0], медиана уровня экспрессии PD-L1 на лимфоцитах микроокружения опухоли составила 5,0% [1,0-11,0], а медиана относительного индекса CPS — 18,0 [3,0-7,8].
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