Pd-Catalyzed Directed Thiocyanation Reaction by C-H Bond Activation.

Abstract

The Pd‐catalyzed directed thiocyanation reaction of arenes and heteroarenes by C−H bond activation was achieved. In the presence of an electrophilic SCN source, this original methodology offered an efficient tool to access a panel of functionalized thiocyanated compounds (21 examples, up to 78 % yield). Post‐functionalization reactions further demonstrated the synthetic utility of the approach by converting the SCN‐containing molecules into value‐added scaffolds.