Pd-catalyzed allylic alkylation of dienyl carbonates with nitromethane with high C-5 regioselectivity

Abstract

A highly regioselective palladium-catalyzed allylic alkylation of dienyl esters with nitromethane has been developed, providing selective access to the C-5 attacked products. The structures of the ligands as well as the steric effect of the substrates are important factors in determining the regiochemical outcome of the reaction.