Pd/C-catalyzed ligand-free and aerobic Suzuki reaction in water

Abstract

A general and efficient catalytic system for Pd/C-catalyzed ligand-free aerobic Suzuki cross-coupling reactions was developed. The reaction tolerated a wide range of aryl bromides with a hydrophilic group or a hydrophobic group without any additives in water. Moreover, the catalytic system was successfully extended to the cross-couplings of heteroaryl halides with various arylboronic acids. The Pd/C catalyst could be reuse three times without significant loss of catalytic activity. A highly efficient and recyclable catalytic system for the Pd/C-catalyzed, ligand-free Suzuki reaction was developed; a wide range of aryl bromides were tolerated, and the reaction proceeded without any additives in water.