PCSK9 levels and markers of inflammation, oxidative stress and endothelial dysfunction in a population of non-dialysis chronic kidney disease patients: Is there an association?

E Dounousi,C Tellis,P Pavlakou,A Duni,V Liakopoulos,A Papagianni,A Tselepis

doi:10.1016/j.atherosclerosis.2021.06.215

PCSK9 levels and markers of inflammation, oxidative stress and endothelial dysfunction in a population of non-dialysis chronic kidney disease patients: Is there an association?

E Dounousi, C Tellis + Show 5 more

https://doi.org/10.1016/j.atherosclerosis.2021.06.215

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Journal: Atherosclerosis

Publication Date: Aug 1, 2021

Affiliation: University of Ioannina, University of Patras, Aristotle University of Thessaloniki

#Proprotein Convertase Subtilisin/kexin 9 Levels #Proprotein Convertase Subtilisin/kexin 9 + Show 8 more

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Abstract

Background and Aims: Proprotein convertase subtilisin/kexin 9 (PCSK9) plays an important role in lipid metabolism while available literature regarding its involvement in the pathogenesis of atherosclerosis and in the expression of genes associated with apoptosis and inflammation is constantly increasing. In the present cross-sectional study, we investigated the possible association of serum PCSK9 levels with markers of inflammation, oxidative stress and endothelial damage in patients with CKD.

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