Abstract
When assessing the efficacy of a treatment in any clinical trial, in addition to hard clinical endpoints, patient relevant outcomes such as quality of life, are also valuable to several stakeholders. However, combining outcomes in a multicomponent endpoint is limited in several ways, not the least in the number and type of endpoints that can be combined. Recently, a class of non-parametric generalized pairwise comparisons (GPC) tests haven been proposed that allow for any number and type of outcomes, including patient relevant outcomes, and has good small sample properties. Our objective is to use the GPC methodology to integrate patient-reported outcomes in a multicomponent analysis.
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