Abstract
BackgroundThe exact biological role of PCOLCE was not yet clear and there were few reports study the correlation of PCOLCE gene expression level with the occurrence and development of gastric cancer.MethodsThe expression of PCOLCE was analyzed by performing the Oncomine and Ualcan database. We evaluated the function of PCOLCE on clinical prognosis with the use of Kaplan–Meier plotter database. The relationship between PCOLCE and cancer immune in filtrates was researched by Tumor Immune Estimation Resource (TIMER) site database.ResultsPCOLCE significantly upregulated in gastric cancer patients compared to normal gastric samples. And the increased expression of PCOLCE mRNA was closely linked to shorter overall survival (OS), progress-free survival (PFS) in all gastric cancers. Besides, PCOLCE expression displayed a tight correlation with infiltrating levels of macrophages and dendritic cells (DCs) in gastric cancer. Moreover, PCOLCE expression was positively correlated with diverse immune marker sets in gastric cancer.ConclusionAll the results above suggested that overexpression of PCOLCE indicated unfavorable prognosis in patients with gastric cancer. PCOLCE was correlated with immune infiltrating levels including those of B cells, CD8 + T cells, CD4 + T cells, macrophages, neutrophils, and DCs in gastric cancer patients. All the findings suggested that PCOLCE could be used as a prognostic biomarker for determining prognosis and immune infiltration in gastric cancer. Additionally, PCOLCE expression potentially contributed to the regulation of monocyte, M2 macrophage, Tfh, CD8 + T cell, TAM, Th1 cell Thus PCOLCE is a potential target for gastric cancer therapy and these preliminary findings require further study to determine whether PCOLCE-targeting reagents might be developed for clinical application in gastric cancer.
Highlights
Gastric cancer ranks fifth (5.7%) among the most common cancers in the world and third (8.2%) in cancer caused deaths, its morbidity and mortality have been declining over the past few decades (Ferro et al, 2014; Bray et al, 2018)
In order to better understand the potential mechanisms and relationship of PCOLCE expression in gastric cancer, we explored the association of the PCOLCE expression and clinical characteristics in gastric cancer patients with the Kaplan– Meier plotter databases
While PCOLCE expression had no significant correlations with tumor purity (r = −0.122, P = 1.77e-02). These findings suggested that PCOLCE might play a specific role in immune infiltration in gastric cancer, especially macrophages and dendritic cell
Summary
Gastric cancer ranks fifth (5.7%) among the most common cancers in the world and third (8.2%) in cancer caused deaths, its morbidity and mortality have been declining over the past few decades (Ferro et al, 2014; Bray et al, 2018). Surgical resection combined with perioperative and adjuvant chemotherapy as well as radiotherapy and chemotherapy is an effective method for the treatment of locally advanced gastric cancer (Van Cutsem et al, 2016). The prognosis of patients with advanced gastric cancer is always poor, and the average overall survival time is only 10–12 months (Digklia and Wagner, 2016). Gastric cancer is a complex disease involving environmental factors and genetic variation (Tan and Yeoh, 2015). Understanding the molecular mechanism of gastric cancer is of great significance for finding new therapeutic targets and improving the prognosis of patients. The exact biological role of PCOLCE was not yet clear and there were few reports study the correlation of PCOLCE gene expression level with the occurrence and development of gastric cancer
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