Abstract
Risk factors for bone loss in HIV patients might differ or have a different impact in African descent compared to Caucasian populations. The aim of the paper is to analyze the relevance of risk factors on surrogate markers of bone metabolism in HIV-infected African descent and Caucasian patients. This is a cross-sectional study in a single HIV-specialized research and clinical care center in Munich, Germany. We included 889 patients in the study, among them 771 Caucasians (86.7%). Only in Caucasians lower vitamin D levels [OR: 2.5 (95CI: 1.6-3.7)], lower calcium levels [OR: 1.8 (1.2-2.8)], and the use of tenofovir disoproxil fumarate [OR: 2.8 (1.8-4.4)] were significantly associated with elevated PTH in multivariate analysis. Likewise, only in Caucasians elevated PTH was significantly associated with elevated markers of c-terminal telopeptides of collagen type 1 (β-CTX) [OR: 1.7 (1.0-3.0)]. Effects of traditional risk factors for secondary hyperparathyroidism and increased markers of bone turn-over seem to be less distinct in African descent HIV patients. The clinical impact and generalizability of this finding as well as the significance of vitamin D supplementation in African descent patients therefore warrants further investigation.
Highlights
M Likewise, only in Caucasians elevated PTH o was significantly associated with elevated c markers of c-terminal telopeptides of collagen type 1 (β-CTX) [OR: 1.7 (1.0-3.0)]
From sub-Sahara areas, are known to have low vitamin D levels while, paradoxically, at the same time being at lower risk for osteoporo
Caucasian or African ethnicity, we found in the African population
Summary
M Likewise, only in Caucasians elevated PTH o was significantly associated with elevated c markers of c-terminal telopeptides of collagen type 1 (β-CTX) [OR: 1.7 (1.0-3.0)]. N Effects of traditional risk factors for secondo ary hyperparathyroidism and increased N markers of bone turn-over seem to be less plementation in this subset of patients.[3] a better understanding seems to be important in order to identify patients who could potentially profit from any kind of intervention. This study aimed at describing potential risk factors of low BMD in Caucasian compared to African decent HIVinfected patients in Central Europe and at analyzing their association with surrogate markers of bone catabolism separately for both ethnicities
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