Abstract

The objective of the present study was to assess the patterns of selenium, zinc, and magnesium metabolism in patients with inflammatory ar-thropathies (rheumatoid arthritis, gout, psoriatic arthritis) and polyarthritis through assessment of elemental levels in blood serum and hair. Material and methods. During a study, patients with polyarthritis (n = 128) and inflammatory arthropathies including rheumatoid arthritis (n = 100), psoriatic arthritis (n = 32), gout (n = 135), as well as 110 healthy subjects representing the control group were examined. Assessment of selenium, zinc, and magnesium levels was performed using high-sensitive method of mass spectrometry with inductively-coupled plasma. Results. The obtained data demonstrate that the level of Se in serum of patients with rheumatoid arthritis, psoriatic arthritis, gout, and polyarthritis was %, 11%, 5%, and 9% lower compared to healthy controls. Serum Zn concentrations in patients with rheumatoid arthritis, psoriatic arthritis, and polyarthritis were also lower than in the control group by 7%, 17%, and 7%, respectively. Hair analysis revealed a significant 20% decrease in seleni-um levels in polyarthritis patients compared to controls. Magnesium content in hair of patients with psoriatic arthritis and gout was 41% and 46% lower when compared to healthy examinees, respectively. At the same time, hair Zn levels in examinees suffering from rheumatoid arthritis, psoriatic arthri-tis, gout, and polyarthritis was 7%, 13%, 15%, and 12% lower than in the control group. Conclusion. Therefore, the results of the study demonstrate a significant decline in systemic levels of selenium, zinc, and magnesium, all pos-sessing antioxidant and anti-inflammatory effects, in patients with polyarthritis and inflammatory arthropathies, thus indicative of their potential in-volvement in pathogenesis of the studied diseases.

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