Abstract
Background: Gastroesophageal reflux disease (GERD) has a high prevalence worldwide and plays a major role in the development of Barrett's esophagus (BЕ) and esophageal adenocarcinoma.
 Aims: To evaluate the patterns of esophageal acidification and esophageal motility in patients with BЕ in comparison with various GERD phenotypes and control subjects.
 Materials and methods: 100 patients were examined: 31 patients with nonerosive reflux disease (NERD), 20 patients with erosive reflux disease (ERD), 17 patients with BE, 32 healthy individuals who made up the control group. All patients underwent 24-hours pH-impedance and high-resolution esophageal manometry.
 Results: According to the 24-hour pH-impedanсe, the total time with pH 4 in the esophagus was 1,9% in control patients, 11.6% in the NERD group, 19.35 in the ERD group and 28% in patients with BE. The average number of acid refluxes was 18.0 in the control group, 58.0 in the group with NERD, 78. in the group with ERD and 89.0 in patients with BE. The number of acidic refluxes was significantly correlated with the time on the acidification of the esophagus (r = 0.5439; p0.05). The analysis of the mean nocturnal baseline impedance (MNBI) revealed a tendency to decrease the values in patients with GERD relative to the control subjects, and there was a decrease in the values of MNBI as the severity of GERD from NERD to ERD and BE (p0.05). Manometric signs of hiatal hernia and/or hypotension of the lower esophageal sphincter were more often registered in the groups of patients with ERD (70%) and BE (65%) than in patients with NERD (32%) and in control group (12%).
 Conclusions: Increase in level of total time with pH 4, number of acid refluxes, reduced values of MNBI, as well as disorders of the structure and function of the esophagogastric junction and motility of the esophagus are associated with the severity of esophagus diseases.
Highlights
Gastroesophageal reflux disease (GERD) has a high prevalence worldwide and plays a major role in the development of Barrett’s esophagus (BЕ) and, as a consequence, esophageal adenocarcinoma
100 patients were examined: 31 patients with nonerosive reflux disease (NERD), 20 patients with erosive reflux disease (ERD), 17 patients with BE, 32 healthy individuals who made up the control group
According to the 24-hour pH-impedanсe, the total time with pH < 4 in the esophagus was 1.9% in control patients, 11.6% in the NERD group, 19.35 in the ERD group and 28% in patients with BE (p < 0.05)
Summary
Вестник РАМН. — 2020. — Т.75. — No2. — С. 96–105. Annals of the Russian Academy of Medical Sciences. 2020;75(2):105. Цель ― оценить характер эзофагеальной ацидификации и моторики пищевода у пациентов с пищеводом Барретта в сравнении с различными фенотипами ГЭРБ и лицами контроля. Статистически достоверные различия в исследуемых показателях были отмечены при сравнении пациентов с пищеводом Барретта и лицами контроля, а также группой неэрозивной рефлюксной болезни (p < 0,05). Частота таких двигательных нарушений грудного отдела пищевода, как неэффективная моторика и отсутствие сократимости, достоверно чаще наблюдалась у пациентов с эрозивной рефлюксной болезнью и пищеводом Барретта (75 и 77% соответственно) в сравнении с больными неэрозивной рефлюксной болезнью (22,5%) и лицами контроля (12,5%). (Для цитирования: Маев И.В., Баркалова Е.В., Кучерявый Ю.А., Овсепян М.А., Андреев Д.Н., Мовтаева П.Р., Шабуров Р.И. Patterns of Esophageal Acidification and Impairment of Esophageal Motility in Gastroesophageal Reflux Disease and Barrett’s Esophagus
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
