Correlation study between upper/lower esophageal sphincter pressure and gastroesophageal reflux disease with or without esophageal mucosal injury

Abstract

Objective To study esophageal motility differences with or without esophageal mucosa injury in gastroesophageal reflux disease (GERD). Methods A retrospective analysis of patients with symptoms such as acid reflux, heartburn, chest pain and other symptoms was performed in the PLA General Hospital from January 2015 to December 2017. The 24-hour esophageal pH monitoring had a Demeester score ≥14.72 points. The erosive esophagus was classified according to endoscopic findings. In the erosive reflux disease (ERD) group and non-erosive reflux disease (NERD) group, changes in esophageal kinetic parameters were compared between the two groups. Results The average value of UESP in NERD group and ERD group was similar, with no significant difference (P=0.168). The UESRP, LESP, LESP, LESRP, LESRP and DCI were higher in NERD group than those in ERD group (P<0.001). The average age of NERD group was significantly lower than ERD group (P<0.000 1), with statistical significance. The height of NERD group was lower than ERD group, and the body weight and the BMI were both smaller in NERD group. The data of three groups were statistically significant. Conclusion With age growing and BMI increasing, the severity of GERD may be worse. In addition, the upper and lower esophageal sphincter dysfunction in patients with ERD are more critical than NERD. Key words: Gastroesophageal reflux disease; Upper esophageal sphincter; Lower esophageal sphincter; High-resolution esophageal manometry