Pattern recognition of HER-1 in biological fluids using stochastic sensing

Abstract

Stochastic sensing was employed for pattern recognition of HER-1 in biological fluids. Nanostructured materials such as 5,10,15,20-tetraphenyl-21H,23H-porphyrin, maltodextrin and α-cyclodextrin were used to modify diamond paste for stochastic sensing of HER-1. Pattern recognition of HER-1 in biological fluids was performed in a linear concentration range between 5.60 × 10−11 and 9.72 × 10−7 mg ml−1. The lower limits of determination (10−12 mg ml−1 magnitude order) were recorded when maltodextrin and α-cyclodextrin were used for stochastic sensing. The pattern recognition test of HER-1 in biological fluids samples shows high reliability for both qualitative and quantitative assay.