Abstract
The nervous system is sensitive to many exogenous toxins in the environment, as well as toxic voluntarily consumed recreationally. Although the blood-brain barrier separates the brain from the rest of the body, possibly due to the high cerebral blood volume are multiple neurological manifestations derived drug and external agents. In general, the neurological manifestations resulting from exposure to exogenous drugs can be toxic and acute and chronic and depend largely on the dose and exposure time, but also on the chemical structure of the neurotoxin, capable of selectively damage a neuronal groups and not others. In this update the neurological manifestations of the main exogenous toxins poisoning and drug use, with greater emphasis on alcohol toxicity, to be the most abused drug in Spain together with the snuff are reviewed.
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