Abstract
Vascular endothelium forms a continuous cellular interface between the circulating blood elements and the surrounding tissues. Endothelium forms a nonthrombogenic surface and selective permeability barrier capable of modulating vascular reactivity and blood flow. The integrity of the endothelium is fundamental for the maintenance of normal homeostasis. Injury to this lining results in dramatic changes in the functional characteristics of the endothelium, rendering it adhesive and prothrombotic. These changes may result from molecules inducibly expressed or simply secreted by injured endothelium. These initial events are correlated with subsequent inflammatatory and proliferative cellular changes associated with the development of vascular pathology.
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