Abstract
Pathophysiology of Spinal Cord Injuries and the Basis for Therapy
Highlights
In order to understand just what happens when a patient experiences a spinal cord injury, one has to comprehend the injury pathophysiology
What is meant by spinal shock? In the acute phase after a severe spinal cord injury, the spinal cord cannot function properly due to a lack of oxygen and nutrients to the tissues
The spinal cord injury causes an overproduction of these free radicals, which attack and disable molecules crucial for cell function by modifying their structure
Summary
In order to understand just what happens when a patient experiences a spinal cord injury, one has to comprehend the injury pathophysiology. It is the death of the neurons that causes the losses of motor and sensory functions after the spinal cord injury (Faden AI, 1988). The spinal cord injury causes an overproduction of these free radicals, which attack and disable molecules crucial for cell function by modifying their structure. Oligodendrocytes in the damaged areas of the spinal cord are killed which means that the cells forming the myelin for the axons are no longer available.
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