Abstract
The story of vascular ageing was first described in the seventeenth century when Thomas Sydenham wrote that ‘A man is as old as his arteries’. This aphorism was returned to publicity lately when Peter Nilsson reintroduced the concept of early vascular ageing. As vascular ageing is described a gradual process involving biochemical, enzymatic, and cellular changes of the vasculature and modification of the signals that modulate them. In susceptible individuals this process appears to be accelerated, leading to features that comprise a condition characterized as early vascular aging (EVA). Early vascular ageing represents the acceleration of the vascular ageing process.
Highlights
The incidence of cardiovascular diseases such as stroke, hypertension, and coronary heart disease is increasing over the years and is more common in the elderly
The story of vascular ageing was first described in the seventeenth century when Thomas Sydenham wrote that ‘A man is as old as his arteries’ [1]
This aphorism was returned to publicity lately when Nilsson et al [2] reintroduced the concept of early vascular ageing
Summary
The incidence of cardiovascular diseases such as stroke, hypertension, and coronary heart disease is increasing over the years and is more common in the elderly. It has been observed that vascular alterations that occur in apparently otherwise healthy senior people, including an increase in stiffness and thickness of large arteries as well as endothelial dysfunction, seem to be more extensive in patients with hypertension or atherosclerosis at an earlier age [4]. In this review we are going to analyze possible pathophysiological mechanisms of early vascular ageing and the relationship of arterial stiffness to cardiovascular events.
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