Abstract
The current study was conducted on fifteen adult male rabbits (2-3 kg), divided into 3 equal groups (control group, group A ‘seven days’ & group B ‘fourteen days group’), removing of the testes and thyroidectomy have been made to both A and B groups. Results indicated that several clear histopathological changes have been observed in the testicular tissues including, complete suppression of spermatogenesis with vacuolar degeneration of epithelial lining of seminiferous tubules in both groups. Moreover, a multinucleated giant cell spermatid in the lumen of seminiferous tubules was featured with no sperm was detected in the lumen of group B. It has been concluded, that the thyroidectomy can cause serious effects on male sexual organs due to diminishing of sex hormones responsible to it growth.
Highlights
The testes are essential sex organs, the main function is the production of male gametes and synthesis and controlled liberation of the androgen (1)
The result of this study showed several histopathological changes on testicular tissues, the results were explained according to the periods after thyroidectomy as below: Control group: The control group showed normal architecture of seminiferous tubules and composition of all stages of spermatogenesis in the lumen of seminiferous tubules (Fig.3)
The histopathological results indicated a marked suppression of spermatogenesis of seminiferous tubules in 7 days and 14 days of the experiment, that may as a result of the thyroidectomy which leads to inhibit the spermatogenesis due to lack in T3 hormone these findings was agreed with (9) who mentioned that the thyroidectomy was resulted in inhibition of gametogenesis and reflected a widespread regression of spermatogenic cells
Summary
The testes are essential sex organs, the main function is the production of male gametes and synthesis and controlled liberation of the androgen (testosterone) (1). Thyroid hormone plays a critical role in coordinating, advancement, differentiation, and metabolism in multiple organs. The testis was regarded as a thyroid hormone not responsive organ for last to decades,recently recorded investigations have confirmed the being of thyroid hormone functional receptors (TRs) in the testis (4). The study results reveal that thyroid hormones play a critical role in sexual organ function. Studies have testified that (T3) is one of the thyroid hormones that regulate Sertoli cell proliferation and differentiation amid testis advancement including the assembly of the blood-testis barrier (5). The main goal of the current study was to clarify the effect of thyroidectomy on spermatogenesis in male rabbits
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