Pathologic study of intravascular coagulation following incompatible blood transfusion in dogs: II. Intra-aortic injection of incompatible blood

Abstract

Intravascular thrombosis follows the injection of incompatible blood into the aorta of the dog. The thrombi form quickly and may disappear quickly. Under different experimental conditions thrombi persist in different locations. The organ or organs through which the coagulating blood circulates first receive and retain the majority of the thrombi. The functional and pathologic consequences of the injection of incompatible blood depend upon the organ or organs which are most severely involved by the clotting process. The localization of thrombi is dependent on the site and speed of injection, and the condition of the vascular bed at the time of the clotting episode. The most likely source of the clotting agent in these experiments is the hemolyzed human red blood cell.