Abstract
In a rare emergency situation, incompatible blood must be intentionally administered as a life-saving measure. This case report describes a 28-yearold woman with multiple significant red blood cell ailoantibodies (anti-K, −Fya, −Jkb, −e , −C, −S) and severe obstetric hemorrhage who, in the opinion of the attending surgeon, required six units of incompatible blood as a life-saving measure. Although a significant transient hyperbilirubinemia developed following the incompatible transfusions, no other obvious untoward problems developed. Renal function as measured by urine output, blood urea nitrogen, and serum creatinine remained within normal limits. No coagulopathy was detected. This case demonstrates that the morbidity associated with incompatible blood transfusions may be minimized by a knowledge of the hemolytic potential of red cell ailoantibodies. Such knowledge may also help avoid delaying needed transfusions to patients for whom only incompatible blood is immediately available.
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