Abstract
Pathogenic microRNAs Common to Brain and Retinal Degeneration; Recent Observations in Alzheimer's Disease and Age-Related Macular Degeneration.
Highlights
Reviewed by: Kin Chiu, Specialty section: This article was submitted to Neurodegeneration, a section of the journal Frontiers in Neurology
Pathologically upregulated miRNAs common to both the prototypic age-related inflammatory degeneration of the brain in Alzheimer’s disease (AD) and of the retina in age-related macular degeneration (AMD) appear to be associated with deficits in the expression of messenger RNA and gene families involved in the innate-immune response, inflammation, neurotrophism, synaptogenesis, and amyloidogenesis (Figure 1)
In this “Opinion” paper for the Frontiers in Neurology Special Research Topic, we will highlight some of the most recent work in this research area, with emphasis on a family of five up-regulated pro-inflammatory miRNAs – miRNA-9, miRNA-34a, miRNA-125b, miRNA-146a, and miRNA-155 – that are emerging as key mechanistic contributors to the AD and AMD process
Summary
Reviewed by: Kin Chiu, Specialty section: This article was submitted to Neurodegeneration, a section of the journal Frontiers in Neurology.
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