Pathogenetic Mechanisms of Organ Dysfunction in Severe Concomitant Trauma

Abstract

Severe concomitant trauma has been a major demographic and medical problem for many years , being the cause of high mortality of the able-bodied population . The simultaneous formation of an array of destroyed tissues triggers a systemic inflammatory reaction , which , against the background of traumatic and hemorrhagic shock , leads to an imbalance in immune reactivity and predisposes to the development of septic complications . The review presents the basic concepts of post-traumatic reactions and violations of the balance of cellular and humoral immune mechanisms leading to the development of complications .