Abstract
Anemia, splenomegaly and glomerulonephritis in acute Plasmodium gallinaceum infections of chickens were studied in association with cold-active hemagglutinin for trypsinized human “O” erythrocytes, serum antigen, and the concurrent presence of antibody to serum antigen, as well as with the parasitemia of acute infection. Anemia with splenic enlargement was produced in normal chickens within 24 hours by intravenous injection of malarious chicken plasma that contained high titers of hemagglutinin, serum antigen, and antibody. A similar anemia and splenic engorgement resulted in normal birds injected with eluates from the washed blood cells of malarious chickens. Within 24 hours, the malarious plasma produced an acute glomerulonephritis similar to that which had been observed on the 5th day of infection. The concurrent presence of the hemagglutinin, serum antigen, and its antibody in the injected plasma, and the failure of the plasma to produce nephritis in immunized chickens, suggested that immune substances might be causal in acute malarial anemia and nephritis.
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