Pathogenesis and therapy of bronchopulmonary dysplasia in preterm infants

Abstract

The incidence of bronchopulmonary dysplasia is very high, and is still the major cause of chronic pulmonary disease in infancy.Although the mechanism is not completely clear.Recent studies have demonstrated that preterm delivery, immature lung development, postnatal injury from mechanical ventilation, oxygen exposure, infection and inflammatory response contribute to it.The association between BPD and genetics reported recently.However, relative therapeutic methods are rarely reported.This review summarizes the pathogenesis and therapy of BPD. Key words: Preterm infants; Bronchopulmonary dysplasia; Risk factor; Therapy