Abstract
The present study was carried out to elucidate the effects of pendimethalin and cadmium chloride on patho-morphological changes in various organs of broiler chicks and their amelioration by vitamin E, selenium and turmeric. Seventy two day old broiler chicks of either sex were randomly divided into six groups, viz groups I to VI, each comprising of 12 birds. Group I: control and given basal diet; Group II: Group I + cadmium chloride @ 500 ppm + pendimethalin @ 1000 ppm; Group III: Group I + cadmium chloride and pendimethalin each @1000 ppm; Group IV: Group II + vitamin E-Selenium @125 mg/kg; Group V: Group IV + Turmeric @ 0.5%; Group VI: Group IV + Turmeric @ 1%. Six birds from each group were sacrificed randomly at 21 and 42 days post exposure and their gross and microscopic alterations in liver, kidney, lungs, heart, gizzard, bursa and thymus were recorded. The main target organs affected were kidney, liver, heart, lung and bursa of Fabricius. Grossly, haemorrhages and fatty changes were observed in combined toxicity groups (500ppm and 1000ppm cadmiumchloride along with pendimethalin) and in the vitamin E-selenium alone group in the 6th week of toxicity. It is proposed that combined toxicity at higher concentration causes severe degenerative changes and ameliorative effects of vitamin E-selenium along with turmeric were meager. The ameliorative effect of turmeric was best observed in sub-acute toxicity of 21 days at 1% conc. Turmeric at 1% conc. did not show any reparative changes in chronic toxicity of 42 days.
Published Version
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