Abstract
SummaryNovelty: Nonphosphorus containing compounds are disclosed as squalene synthetase inhibitors.Biology: The compounds are proposed for the treatment of arteriosclerosis, hyperlipidaemia and also fungal infections. The intrinsic squalene synthetase inhibitory activity is measured in a standard in vitro protocol using male Charles Rivers CD rats. Data are presented in tables.Chemistry: The novel nonphosphorus containing compounds are prepared by aerobic fermentation of Sporormiella intermedia, a bitunicate ascomycete or other organisms of the same genera.
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