Abstract
SummarySummaryNovelty: Analogues of lipid A useful as anti-endotoxic drugs for the treatment of septic shock and lipopolysaccharide (LPS)-mediated activation of viral infection (HIV, herpes or influenza) are disclosed.Biology: The compounds were assayed for their ability to inhibit LPS-induced production of tumour necrosis factor and IL-1β both in vitro and in vivo. One compound effectively inhibited TNF production in mice with an ED50 value of 5.4μg/mouse.Chemistry: The synthesis of the compounds are described in three examples including that of analogue B318.
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