Abstract
SummarySummaryNovelty: Novel benzimidazoles are disclosed as K+ channel activators. These compounds are said to be useful for the treatment of convulsions, asthma, hypertension and ischaemia.Biology: Activity as potent openers of the high conductance, Ca-activated, K+ channel was demonstrated in vitro using NIE-115 neuroblastoma cells. Test compound-induced hyperpolarization was —14 mV at a dose of 30 μM. Further tests were performed on inside-out patches of cerebellar granule cell membrane, cultured bovine aortic and guinea pig tracheal smooth muscle cells; these tests showed that the K+ channel was significantly activated.Chemistry: Eighteen examples are given for preparation of the compounds by conventional methods. Characterization is by mp. The specified compound is 1-(5-chloro-2-hydroxyphenyl)-5-trifluoromethyl-1,3-dihydro-2H-benzimidazol-2-one.Structure:
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
