Abstract
SummaryNovelty: A composition consisting of silver, gold and copper complexes of phosphinohydrocarbon derivatives which inhibit the growth of tumour cells, e.g. B16 melanoma, P388 leukaemia and M5076 reticulum cell sarcoma, are disclosed.Biology: Compound A is evaluated in an in vivo P388 leukaemia model at the maximum tolerated dose (MTD) of 2 mg/kg (increase in lifespan (ILS) of 83%). In a M5076 reticulum cell sarcoma assay, MTD=2 mg/kg and ILS=47–83%, and in an in vivo, ip, B16 melanoma assay, MTD=2 mg/kg and ILS=28–50%. In a mammary adenocarcinoma 16/c in mice, compound A at 8 mg/kg ip x 5 inhibits growth 100% with no detectable tumours at twenty-one days. This result is compared with cisplatin (6 mg/kg ip x 5) which shows 37% inhibition.Chemistry: Bi-(1,2-bis(diphenylphosphino)ethane)gold(I) chloride (compound A) is exemplified.
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