Abstract
To the Editor.— The letter on the sensitivity of the enzyme-multiplied immunoassay technique (EMIT) in detecting the presence of cannabinoids in the urine of persons who have passively inhaled marijuana smoke points to the need for further study of the issue (1983;249:475). The authors' research suggests that it is highly unlikely that a person could passively inhale enough marijuana smoke to have a positive test result by the EMIT cannabinoid assay. It has been reported elsewhere that passive inhalation of marijuana smoke by a marijuana-naive subject can result in the presence of substantial quantities of cannabinoids in urine. 1 In this study, the urinary concentration of cannabinoids in a passive smoker was reported to be as high as 260 ng/mL, well in excess of the cutoff for a positive EMIT result regardless of whether the calibration is 20 or 50 ng/mL. Many factors influence the concentration of cannabinoids in urine:
Published Version
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