Abstract
Introduction: Tuberculosis and sickle cell disease are one of the main global health priorities particularly in Africa. We aimed to determine the epidemiological, diagnostic and therapeutic aspects of tuberculosis in children and adolescents with sickle cell disease. Patients and methods: Patients aged 0 - 20 years with sickle cell anemia presented with tuberculosis at the Centre Hospitalier National d’Enfants Albert Royer (CHNEAR), Dakar, Senegal were included in the study. Medical history, risk factors, clinical, bacteriological, and outcome data was collected. Data was analyzed using the SPSS software, version 16. Results: A total of 25 cases of tuberculosis were documented from January 1st, 1991 to December 31st, 2019 (hospital prevalence: 0.97%). Mean age was 12.5 years. The sex ratio was 1.5 (15 girls and 10 boys). Pulmonary tuberculosis in 14 cases was the most frequent followed by lymph nodes in 7 cases involvement and Pott’s disease in 4 cases. In 5 patients Tb was multifocal. Mean duration of treatment was 8.27 months (6 to 12 months). Outcome was good on antituberculosis treatment. None patient died. Conclusion: Children and adolescents with sickle cell disease can be infected with Mycobacterium tuberculosis. Pulmonary tuberculosis, lymph nodes and bone involvement are the most frequent localizations. Outcome is good on antituberculosis treatment.
Highlights
Tuberculosis and sickle cell disease are one of the main global health priorities in Africa
Patients and methods: Patients aged 0 - 20 years with sickle cell anemia presented with tuberculosis at the Centre Hospitalier National d’Enfants Albert Royer (CHNEAR), Dakar, Senegal were included in the study
Children and adolescents with sickle cell disease can be infected with Mycobacterium tuberculosis
Summary
Tuberculosis and sickle cell disease are one of the main global health priorities in Africa. We aimed to determine the epidemiological, diagnostic and therapeutic aspects of tuberculosis in children and adolescents with sickle cell disease. Conclusion: Children and adolescents with sickle cell disease can be infected with Mycobacterium tuberculosis. HIV infection, malnutrition, children under 5 years old are main risk factors [2]. In Senegal, the prevalence is about 10% in the general population and 2% of children are born with sickle cell disease major syndrome [6]. The exact prevalence of tuberculosis in children and adolescent with sickle cell disease is unknowns. The aim of this study is to determine the epidemiological, diagnostic, therapeutic and evolutionary aspects of tuberculosis in children and adolescents with sickle cell disease in a pediatric hospital of Dakar
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
