Particle Size Effect of Micro and Nano Aluminium Oxides on Antioxidant Defence System of Model Organism Galleria mellonella

Abstract

Studies on heavy metal toxicity show that toxicity of nanoparticles compared to micro form have hypothesis regarding nanoparticles are more efficient on the oxidative stress. The aim of the study was to compare the toxic effects of nano and micro particles of Al2O3 and tissue differences on oxidative stress using model organism Galleria mellonella larvae. The study presented that Al2O3 NPs increased the antioxidant enzyme activities in the fat body of larvae, whereas Al2O3 MPs increased the enzyme activities in the midgut of larvae. In conclusion, heavy metal toxicity depends on the particle size, as well as tissue differences.