Abstract
A recent evaluation of a new in situ particle viewer (ISPV) system for the examination of particle shape and its subsequent development during crystal growth is presented. Precharacterization studies using conventional and hot-stage microscopy reveal that the ISPV probe system together with a commercial image analysis software is capable of generating representative high-quality images which can be processed and analysed. ISPV studies of the batch crystallization of l-glutamic acid in a 20-L reactor are shown to be able to characterise effectively crystallization and polymorphic phase transformation processes, revealing potential applications in both small- and large-scale reactor systems. Some improvements to the probe, such as increasing the resolution and reducing the encrustation using thermal coating, are suggested.
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