Particle manipulation via integration of electroosmotic flow of power-law fluids with standing surface acoustic waves (SSAW)

Abstract

Standing surface acoustic wave (SSAW) based microfluidic devices have shown great promise toward fluid and particle manipulation applications in medicine, chemistry, and biotechnology. In this article, we present an analytical model for investigating continuous manipulation of particles (both synthetic and biological) within electroosmotic flow of non-Newtonian bio-fluids in a microfluidic channel under the influence of standing surface acoustic waves (SSAW). The particles are injected along the center of channel into the electroosmotically driven flow of power-law fluids, wherein their transport through the SSAW region is dictated by the hydrodynamic, electrophoretic, and acoustic forces. We first present a mathematical model to analyze the characteristics of electroosmotic flow of non-Newtonian power-law fluids in a hydrophobic slit microchannel. Next, we investigate the trajectories of particles in the flow field due to the combined effect of electroosmotic, electrophoretic, and acoustophoretic forcing mechanisms. The effect of key parameters such as particle size, their physical properties, input power, flow rate, and flow behavior index on the particle trajectories is examined while including the effect of the channel walls. The presented model delineates the methodologies of improving SSAW-based particle separation technology by considering the fluid rheology as well as the surface properties of the channel walls. Therefore, we believe that this model can serve as an efficient tool for device design and quick optimizations to explore novel applications concerning the integration of electroosmotic flows with acoustofluidic technologies.