Abstract
There are morphofunctional zones in organism tissues, where proliferation and differentiation processes occur. Daughter cells are differentiated in the electric field excited by 12 mother and daughter cell pairs, which turned out at cambial cell division. With aging, the cambial cell number is reduced to 7, which is close to threshold level (6 cells), at which the differentiation of daughter cells is absent. The depression of cambial cell number with aging is connected with the work of another morphofunctional zone—the hypothalamus, which is the major center of vegetative regulation and initially has very high RhoA activity, which has been established in embryogenesis. Estrogens, influencing over the hypothalamus and activating Src kinase in its nuclei, reduce level of RhoA activity, including SCN, responsible for many biorhythms of an organism. As a result, the hyperestrogenemia and therefore a connective tissue at first occur. Then there happens a hypoestrogenemia that leads to sharp falling of proliferative activity of cells, causing the depression of cambial cell number and possibility of a malignant tumor development. Along with this, there are the deep lesions of hormone regulation, leading to some lethal diseases. Thus, the RhoA increasing in hypothalamus and especially in SCN circadian rhythm can counteract the Src kinase intensifying and prevent the processes connected with this.
Highlights
Structure and Function of Skin Morphofunctional ZonesThe spatial organization of different tissues had been revealed [1]
In our previous research, the spatial organization of different tissues had been revealed [1]
Differentiation of daughter cells can be passed in an electric field excited by 12 mother and daughter cell pairs, which are disposed in the same subunit
Summary
The spatial organization of different tissues had been revealed [1]. In the functioning of morphofunctional zone it may be distinguished by two key proteins: tyrosine kinase Src and RhoA, which participate in various paths of transduction and provide the development of cell microfilaments [1] These proteins define a direction of a long axis of cambial cell which unlike the other cells is normal with the basal membrane, instead of parallel with it. It is known that blastomere which receives a part of egg cytoplasm, including sperm tail, enters the second division faster than a sister blastomere [2] It happens because the sperm tail consists of microtubules in which formation of Src kinase participates, providing a cytokinesis. Descendants of these cells always enter division faster than the others, which lead to separation of zone into two subunits
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