Abstract
Sound speeds have been measured for aqueous solutions of five tetrapeptides and five pentapeptides at T=298.15 K. The partial molar isentropic compressions at infinite dilution, \(K_{S,2}^{\circ}\), were derived for the peptides using conventional methods. The results were compared with those calculated using group additivity methods, with the amino acid side-chain contributions derived using \(K_{S,2}^{\circ}\) data reported previously for some tripeptides of sequence gly-X-gly, where X represents an amino acid, and also for some N-acetyl amino acid amides. The tripeptides are the preferred model compounds for the estimation of the side-chain contributions to \(K_{S,2}^{\circ}\) of a polypeptide. Our study also confirms that simple group additivity schemes are not feasible for the estimation of \(K_{S,2}^{\circ}\) values for polypeptides and unfolded proteins.
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