Abstract

Polyethylene glycols (PEG) are neutral polymers used in a variety of single-channel conductance measurements, to change solution conductivity and viscosity, to induce osmotic stress in polymer-excluded regions, or simply as crowding agents. Many of the above applications involve the proximity of neutral polymers to charged membranes or their confinement in aqueous pores formed by protein channels with charged residues. A well-known phenomenon relevant to this problem is the polarization of a neutral particle with dielectric properties different from the surrounding medium under the effect of an electric field.

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