Abstract
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hemolytic disorder of acquired origin and is clinically manifested by chronic hemolysis, thromboses in various sites, and bone marrow failure. The disease is so rare that the delay in the diagnosis is not uncommon and this bears a tremendous impact on patient management. We present this case to draw attention to this uncommon cause of hemolytic anemia, which should be considered in any patient, of any age, who has signs of chronic hemolysis.
Highlights
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hemopoietic stem cell disorder characterized clinically by chronic hemolytic anemia with acute episodes, thrombosis and bone marrow failure
We present this rare cause of hemolytic anemia, which should be considered in any patient, of any age, who has signs of chronic hemolysis
Paroxysmal nocturnal hemoglobulinuria (PNH) is a hematopoeitic stem cell disorder characterized by the formation of defective erythrocytes, granulocytes, and platelets
Summary
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hemopoietic stem cell disorder characterized clinically by chronic hemolytic anemia with acute episodes, thrombosis and bone marrow failure. We present this rare cause of hemolytic anemia, which should be considered in any patient, of any age, who has signs of chronic hemolysis. With these features of pancytopenia and hemolysis, bone marrow aspiration was performed, which revealed erythroid hyperplasia.
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